PPA (Phenylpropanolamine)

PPA (Phenylpropanolamine)


PPA is used in the treatment of hormone-based urinary incontinence in dogs.  In most cases, incontinence resolves for a period of 8 – 24 hours after administration.  PPA works by increasing the muscle tone of the urethra.


PPA is administered orally.  Palatable pills are readily available.

Side Effects

Side effects of PPA are uncommon, but include gastrointestinal upset (diarrhea or vomiting), restlessness, agitation, and appetite suppression.  The likelihood of side effects may be reduced by administering the medication with food.

Contact your veterinarian immediately if you suspect that your pet is suffering side effects from PPA.


After being diagnosed with hormone-based urinary incontinence, most dogs require long-term treatment with PPA.  Most veterinarians encourage owners to use the minimum effective dose and frequency of the medication.

Dogs that take PPA regularly may require periodic blood and urine tests to ensure proper function of the liver and kidneys.

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The contents of this page are provided for general informational purposes only. Under no circumstances should this page be substituted for professional consultation with a veterinarian.